Below note was so well thought out i thought i would share as i have had this question many times over the years. She is answering the question on why different types of digestive discomfort for some and not others when taking FCLO.
My personal case from several years ago included i would feel bloated and repeat for hour or better. Today i might repeat one time and all is good. some find taking Swedish Bitters with fclo helps.
I gave her my thoughts based on conversations with many and here is her reply
I would say that you are right to think of the liver and gall bladder. People with issues of low bile secretion either due to low production in the liver or secretion problems of the gall bladder have difficulty digesting fats especially with taken alone. They tend to get diarrhea when they eat fats. If someone has been on a low fat diet for some time, their bile production will be low. They either need to ease into fats or take a bile salts supplement with fats or both. If someone has had their gall bladder removed they need to eat on a schedule as the liver can produce bile on a schedule. It is best to take the oils with other foods, this may help. Maybe this family has a familial bile dysfunction. Maybe they are on or have recently been on a low fat diet.
Dr. Rosann Volmert DO